Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice

A Inglis, R Ubungen, S Farooq, P Mata, J Thiam… - BMC genomics, 2021 - Springer
Obesity is a major risk factor for type 2 diabetes, and the … consist of catecholamines,
neuropeptides and also micro RNAs … gland loss of CHGB in knockout mice was shown to reduce …

Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain

C Eva, A Oberto, A Longo, P Palanza… - … & Biobehavioral Reviews, 2020 - Elsevier
… among the various strains of genetically modified mice and to … pancreatic polypeptides,
that includes peptide YY (PYY) and … /high fat diet (MHF) to male TgY1R/LacZ mice, increased …

Murine models of obesity

T Martins, C Castro-Ribeiro, S Lemos, T Ferreira… - Obesities, 2022 - mdpi.com
… The Tsumura and Suzuki obesity and diabetes (TSOD) strain … of eating, such as the
neuropeptide Y and leptin, are also … with mild renal damage and increased pancreatic islet mass …

Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion

B Thorens - Physiological Reviews, 2024 - journals.physiology.org
… 46 the autonomic innervation of the pancreatic islets; the … can also carry neuropeptides such
as a neuropeptide Y and … of the pathogenesis of obesity and diabetes, as well 246 as of the …

Emerging roles for kisspeptin in metabolism

C Izzi‐Engbeaya, WS Dhillo - The Journal of Physiology, 2022 - Wiley Online Library
… Kisspeptin, a neuropeptide hormone, has been firmly … (including women, people with obesity
and people with diabetes). … A, Pancreas-specific kisspeptin receptor knockout mice develop …

Obesity, POMC, and POMC-processing enzymes: surprising results from animal models

I Lindberg, LD Fricker - Endocrinology, 2021 - academic.oup.com
… are not detected in mouse hypothalamus or pituitary, although a … Because PC1/3 and CPE
process many neuropeptide and … peptidergic differences between these 2 different pancreatic

Sexual dimorphism in adipose-hypothalamic crosstalk and the contribution of aryl hydrocarbon receptor to regulate energy homeostasis

N Haque, SA Tischkau - International journal of molecular sciences, 2022 - mdpi.com
… Overall, this review summarizes sex differences in the … the pancreas circulate in the blood in
proportion to fat mass … CRH induces anorexia in the brain by inhibiting neuropeptide Y (NPY)…

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

EG Mills, C Izzi-Engbeaya, A Abbara… - Nature Reviews …, 2021 - nature.com
… –pituitary–gonadal (HPG) axis and decreases fat mass. … of major appetite-regulating
neuropeptides, with higher agouti-… kisspeptin levels within the pancreas would help to advance …

Conditional inactivation of limbic neuropeptide y-1 receptors increases vulnerability to diet-induced obesity in male mice

S Paterlini, R Panelli, L Gioiosa, S Parmigiani… - International journal of …, 2021 - mdpi.com
… activation of the hypothalamic–pituitary–adrenal (HPA) axis. … functions and markers of type
2 diabetes (see “Materials and … , C57BL/6N derived strain) mice was achieved as previously …

Positive effects of NPY1 receptor activation on islet structure are driven by pancreatic alpha-and beta-cell transdifferentiation in diabetic mice

RA Lafferty, N Tanday, RC Moffett, F Reimann… - Frontiers in …, 2021 - frontiersin.org
… activation of pancreatic beta-cell neuropeptide Y1 receptors (… been confirmed using receptor
knockout cell lines (4). … even within (26), strains of mice, comparable to the established …